powerful!!!
"I had heard so much about Japanese knotweed as a cure for Lyme. I ordered it immediately. The effects were so strong (even though I thought I was doing a good job of titrating), Be careful! It is powerful and it is excellent."
Access Denied
IMPORTANT! If you’re a store owner, please make sure you have Customer accounts enabled in your Store Admin, as you have customer based locks set up with EasyLockdown app. Enable Customer Accounts
MICROBIAL SUPPORT & More
INFLAMMATORY RESPONSE SUPPORT | ANTIOXIDANT SUPPORT | CARDIOVASCULAR SUPPORT
- Supports the body's natural microbial defenses with a well-researched botanical.
- Promotes a healthy inflammatory response*
- Contains naturally occurring polyphenols
- Download the product sheet
Directions
30 drops (1.5 mL) in 4 oz. of water, twice daily, or as directed by a healthcare professional.
Avoid during pregnancy and breastfeeding. Consult a physician before use if taking anticoagulant or antiplatelet medications, estrogen therapy, or CYP-metabolized medications. Not for children under 3.
MICROBIAL SUPPORT
INFLAMMATORY SUPPORT
IMMUNE SUPPORT
Benefits: What’s It For?
Japanese Knotweed (Polygonum cuspidatum) — highly valued for its concentration of resveratrol, emodin, polydatin, and flavonoids — contains potent antioxidants shown to support microbial, immune, and systemic health.*
Researched Microbial Balance
Well-researched botanical traditionally used to support microbial resilience, immune modulation, and systemic wellness.*
Read the white paper
Whole-Root Synergy
Our proprietary, hydro-ethanol extraction process preserves the root’s complete phytochemical profile — enhancing bioavailability and delivering broad-spectrum benefits that isolated compounds can’t match.
Download the product sheet
Pharmaceutical-Grade Manufacturing
Exceptional quality and consistency. Every batch of raw materials undergoes identity verification, microbial testing, and heavy metal analysis at our U.S. facility.
Learn about our process
Microbial, Immune, & Systemic Support
Ideal for addressing ongoing health challenges, our whole-root extract offers researched support for microbial balance, healthy immune function, and cardiometabolic health.*
- Supports healthy microbial balance*
- Promotes a healthy inflammatory response*
- Encourages healthy immune function*
- Provides antioxidant protection*
- Supports cardiovascular and circulatory health*
- Helps maintain healthy blood glucose metabolism*
Pairs well with Cryptolepis - 2oz
Extensively Researched
Carefully Sourced Ingredients
Our Japanese Knotweed extract begins with carefully sourced Polygonum cuspidatum root, harvested at peak maturity to maximize active compound content. Every batch undergoes identity verification and contaminant screening before entering production.
Proprietary Extraction
Refined through decades of experience, our hydro-ethanol extraction process preserves the root’s full profile of polyphenols and anthraquinones — including resveratrol, emodin, polydatin, and flavonoids — to ensure broad-spectrum activity and high bioavailability.
Ingredients
Active Ingredient:
Japanese Knotweed (Polygonum cuspidatum) root extract – 1.5 mL
Other Ingredients:
Mineral water, ethanol (20–24%)
Questions? We have answers.
What is Japanese Knotweed, and how does it support health?
Japanese Knotweed is a clinically studied botanical used in traditional medicine for more than 1,500 years. Its root contains resveratrol, emodin, polydatin, and flavonoids — bioactive compounds that provide broad-spectrum support for microbial balance as well as inflammatory and immune function, cardiovascular health, and healthy blood glucose metabolism.*
Why was this formula developed?
Leading integrative practitioners asked us for a high-quality Japanese Knotweed extract for use in multi-layered microbial and immune support protocols. This formula complements other NutraMedix microbial support formulas.
How is it different from other Japanese Knotweed extracts?
Our proprietary hydro-ethanol extraction process captures the root’s complete profile of bioactive compounds — unlike other extraction methods, which only capture isolated compounds. In addition to delivering broader clinical benefits, this process preserves the natural synergies between each compound, enhancing absorption and bioavailability.*
Is it safe for everyone?
Japanese Knotweed is generally well-tolerated at recommended doses. Not recommended for pregnant or breastfeeding women, children under 3, and patients taking anticoagulants, antiplatelet medications, estrogen therapy, or medications metabolized by CYP450 enzymes.
Research-backed
“I love NutraMedix products. Most importantly, they work. Excellent quality, backed by tremendous research and I’ve just had good success as a clinician.”
Nancy O’Hara, MD, MPH, FAAP
Overall rating: 5.0 / 5 from 1 reviews.
AI Generated Review Summary
Summary topics
Review topics: [].
Review highlights
Reviews
Q&A
Targeted formulas. Complementary pathways.
4 Products in Synergy
-
JAPANESE KNOTWEED
Broad-spectrum root extract that enhances tissue penetration and complements other botanicals for systemic microbial and immune support.*
-
Cryptolepis
Well-researched microbial botanical supporting microbial activity and complementing Japanese Knotweed in comprehensive microbial-balance protocols.*
-
Artemisia Annua
Immune-balancing and inflammation-modulating herb that strengthens microbial defense when paired with Japanese Knotweed and Artemisia Annua.*
-
Baikal Skullcap
Neuroprotective, antioxidant root that supports immune modulation and nervous-system balance within multi-layered microbial protocols.*
Supporting your health journey
Additional Products
Take control of your health
Subscribe to receive educational insights and special promotions!
Invalid password
Enter